So I read last night that Pemphigus is genetic. But I also read that it isn’t. Which one is right?
There’s only one way to find out. Fight!
My opinion. It’s genetic. No doubt. That’s based on my initial thought of “well of course it is” and then backed up by reading that PV (Pemphigus Vulgaris) is endemic in some areas. Given that it’s not an infection it’s an immune disorder, then logically it must be because the people who live in that area share a common gene pool.
Am I right or what?
Unless of course it can be triggered by an insect bite of some sort which also exists in those endemic areas. I would change my mind about this if I saw that evidence – I ALWAYS change my mind given new information, I’m never prejudiced in any way and I have a very scientific way of looking at things. Evidence based mixed with a bit of theory until tested.
But the real proof is this.
https://www.ncbi.nlm.nih.gov/pubmed/15869862
https://rarediseases.info.nih.gov/diseases/7355/pemphigus-vulgaris
Summarised on the second link:-
“Genetic Factors: Predisposition to pemphigus is linked to genetic factors. Certain major histocompatibility complex (MHC) class II molecules, in particular alleles of human leukocyte antigen (HLA) DR4, appear to confer susceptibility to pemphigus vulgaris.”
So there you go. The more you know eh folks?
